Some Myths and Truth about Leptin Resistance You Should Know

Diet Weight LossLeptin or satiety hormone is a hormone that contributes in regulating the energy balance. Leptin hormone is made by adipose cells and works to inhibit hunger. This hormone tells the brain that someone does not need more foods. However, some cases show that this hormone does not work well. This condition is called leptin resistance. People with this leptin condition wants to eat more, even if they have overweight and even obesity.

How Leptin Resistance Affect Weight

Many people may think that those with overweight or obesity have less leptin. It is not true because they actually have a lot of leptins. The fatter they are, the more leptins they have. However, they have leptin resistance, a condition when their brains don’t respond to the signal from leptin to stop eating.

This is also called brain starvation. Those people actually have high leptin but their brain can’t see them. Although they have obese body, the brain is starved. This condition is like insulin resistance in those who have diabetes type 2. Pancreas actually produces insulin, but their body does not respond to it well.

It is not only about the hunger system problem, but also reward system problem. Researchers found that food is more rewarding when the leptin level is low. On the other hand, when the leptin levels are high, food does not look good so that people do not need to eat. However, this rewarding system is broken when they have leptin resistance. Although the leptin levels are high and they try to send signal that they don’t need more foods, the brain can’t get this signal.

Leptin Diet

The, what about taking leptin resistance treatment or leptin supplements? Indeed, leptin was used for obesity treatment. Many scientists believed that adding more leptin would signal the brain to stop overeating. However, this did not work well as giving this hormone only works for rare cases for those that do not have leptin at all. So, it is not about adding supplements, but more about reversing leptin resistance.

What Causes Leptin Resistance

There are some cellular mechanisms that are believed as the factors that cause leptin resistance. There are three factors, i.e. inflammation, free fatty acids and having high leptin. Inflammation that gives signal in hypothalamus seems to be the main cause of this problem.

Besides, elevated free fatty acids can cause broken leptin signaling because they exist in bloodstream and increase the fat metabolites in brain. Additionally, elevated leptin levels in the first place seem to be another cause of this problem.

Honest Review on ASICS Gel Venture 5

This review contains specific detail of asics gel venture 5’s pros and cons, included its ability to provide the ultimate support to run

Asics gel venture 5 is a running shoe which is meant to use for running off-road, which means that it is meant to use in a trail. This is one of the best running shoes to support running in an off-road, because it provides credible durability while used for running the rough roads.

The shoe is not only suitable for rough roads, but it is officially informed that it is also suitable for a long distance running. The runners will like it, because the shoes weigh only 247g which is a light weight. So, when they are running, they will not be bothered by the shoes.

ASICS Mens Gel Venture 5

Detail information of ASICS Gel Venture 5

As it is mentioned earlier, the shoes are made for trail running—off-road running in rough tracks. That is why the shoes have such a tough look on the outside, and it also looks firm. Moreover, the design of the arch is created to support neutral pronation and normal training.

The majority of runners who have bought the shoes claimed that asics gel venture 5 does support a better grip while running. Well, thanks to the arch. Then, regarding to the price, it is sold for about $65, an estimated price.

However, the price can vary depends on the countries. Regarding to its weight, It is light weight, because it weighs only 303g and 247g in W, while the length of the shoes is 10mm and 10mm.

The Pros and Cons of ASICS Gel Venture 5

Based on many reliable sources of asics gel venture 5 review, even though the detail information about the shoes are highly recommendable, there are still some pros and cons to discuss.

ASICS Gel Venture 5


  • Athletes or people who love running in general, love the comfort-ability of the shoes.
  • They admire the ability to give them a better grip than any other running shoes available in market. Because the extreme support provided by the shoes, many people start buying and using it right away.
  • The quality speaks for the truth. Regarding durability, the shoes have what so called the Asics High Abrasion Rubber. This feature’s function is to improve the shoes’ durability.
  • Since it is used for running in rough tracks, the high durability is needed importantly.
  • Moreover, the shoes have a system that can absorb shocks and sudden transition; therefore it also offers safety for runners’ feet.
  • Ultimately, all of these qualities and low price can be yours, because you can have them all only by US$65.
  • The shoes are also available for women. The asics gel venture 5 women is more or less has similar quality.


  • The pros aside, a product will always be reviewed badly and greatly, because there is no room for flaws in running shoes market.
  • While some reviews are saying that they admire asics gel venture 5’s durability of the shoes, some are questioning it.
  • They mentioned that the low price is suspicious. US$65 is not enough to make pair of running shoes from durable material. They claimed that this aspect should be investigated further to decide the truth.
  • Another, it is also very possible to cause you an ankle pain.